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Portfolio – Open Trials

Trial Add-Aspirin Trial
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

Click Here to view Cancer Research UK trial summary
Trial The Adept DDR Trial
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

Accelerating the Development and implementation of Personalised Treatments of DNA Damage Response agents and radiotherapy +/- immunotherapy for head and neck squamous cell cancer

Click Here to view Cancer Research UK trial summary
Trial AMMO
Cancer Type Haematological Cancers
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Study Of ASTX727 Versus Best Supportive Care In MDS/MPN Overlap Syndromes

Trial ATNEC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy

Click Here to view Cancer Research UK trial summary
Trial CAPItello-292
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital
Information

A Phase Ib/III, Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unresectable or Metastatic Breast Cancer

Trial CCLG Tissue Bank
Cancer Type Children’s Cancer
Hospital(s) Royal Belfast Hospital for Sick Children
Information

A National protocol for collecting and banking childhood cancer tissue samples for research (2005 BS 01 – formerly BS 05)(The Children’s Cancer and Leukaemia Group Tissue Bank)

Trial CellCentric
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CLIN-60000-452
Cancer Type Kidney Cancer
Hospital(s) Belfast City Hospital
Information

A prospective observational international study of cabozantinib tablets in combination with nivolumab as first-line treatment of advanced renal cell carcinoma in adults

Trial CONCORDE
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A platform study of DNA damage response inhibitors in combination with conventional radiotherapy in non small cell lung cancer

Click Here to view Cancer Research UK trial summary
Trial CT7001_003
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A Phase 1b/2 Open-label Study of Samuraciclib in Combination with Elacestrant in Participants with
Metastatic or Locally Advanced Hormone Receptor-positive and Human Epidermal Growth Factor
Receptor 2-negative Breast Cancer

Trial DETERMINE
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

Determining Extended Therapeutic indications for Existing drugs in Rare Molecularly-defined Indications using a National Evaluation platform trial

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Trial EndoNET
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital and Belfast City Hospital
Information

Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women

Trial EXCALIBER
Cancer Type Haematological Cancers and Myeloma
Hospital(s) Belfast City Hospital
Information

A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM)

Trial FEDORA
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase II Study To Evaluate The Tolerability, Safety And Activity Of Fedratinib Combined With Ropeginterferon Alfa-2b In Patients With Myelofibrosis

Trial GO44457 MORPHEUS-NEO HCC
Cancer Type Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A Phase Ib/II, open-label, multicenter, randomized platform study evaluating the efficacy and safety of neoadjuvant immunotherapy combinations in patients with surgically resectable hepatoceullular carcinoma

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