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Portfolio – Open Trials

Trial GO44457 MORPHEUS-NEO HCC
Cancer Type Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A Phase Ib/II, open-label, multicenter, randomized platform study evaluating the efficacy and safety of neoadjuvant immunotherapy combinations in patients with surgically resectable hepatoceullular carcinoma

Trial HER2-RADiCAL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

The HER2-RADiCAL study (Response ADaptive CAre pLan) – Tailoring treatment for HER2 positive early breast cancer

Click Here to view Cancer Research UK trial summary
Trial ICHOR
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

Investigation of Circulating Haematological Biomarkers in Cancer

Trial LCH-IV
Cancer Type Children’s Cancer
Hospital(s) Royal Belfast Hospital for Sick Children
Information

International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis

Trial MITHRIDATE
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera

Trial ModiFY Study
Cancer Type Breast Cancer, Head & Neck Cancer, Kidney Cancer, and Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

The ModiFY Study: A phase 1/2, multicentre, open‐label study of Modi‐1 in patients with breast, head and neck, ovarian, or renal cancer

Trial MOSAICC
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Altnagelvin Hospital, Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

MyeloprOliferative NeoplasmS An In-Depth Case-Control Study: A Case-Control Study Of Patients With Myeloproliferative Neoplasms And Non-Blood Relative/Friend Controls

Trial NG11-2-P1b
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

A Phase-1b Dose Escalation Study to Assess the Effect of NG11-2 on Radiation Induced Oral Mucositis in Patients with Head & Neck Cancer

Trial OPTIMA
Cancer Type Breast Cancer
Hospital(s) Ulster Hospital
Information

Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis

Trial PACE-NODES
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A phase III randomised trial of 5 fraction prostate SBRT versus 5 fraction prostate and pelvic nodal SBRT

Trial PACIFIC-9
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III, double-blind, placebo-controlled, Randomized, Multicentre, International Study of Durvalumab Plus Oleclumab and Durvalumab Plus Monalizumab in Patients with Locally Advanced (Stage III), Unresectable, Non-small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Definitive, Platinum-Based Concurrent Chemoradiation Therapy

Click Here to view Cancer Research UK trial summary
Trial Pivotal Boost
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III Randomised Controlled Trial of Prostate and Pelvis Versus Prostate Alone Radiotherapy With Or Without Prostate Boost

Trial PLATFORM
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

Trial POETIC-A
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Pre-Operative Endocrine Therapy for Individualised Care with Abemaciclib

Click Here to view Cancer Research UK trial summary
Trial Pola-R-ICE
Cancer Type Lymphoma
Hospital(s) Belfast City Hospital
Information

An open-label, prospective Phase III clinical study to compare polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (Pola-R-ICE) with rituximab, ifosfamide, carboplatin and etoposide (R-ICE) alone as salvage therapy in patients with primary refractory or relapsed diffuse large B-cell lymphoma (DLBCL)

Click Here to view Cancer Research UK trial summary

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